Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.50 |
| ▸ | HTR2C | P28335 | 4/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 2/20 | 0.41 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 4/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27708455 | 0.87 | KDM1A (0.43) | HTR2AHTR2CHTR2BPARP10PARP1 | |
| SCHEMBL27780964 | 0.83 | PNMT (0.44) | HTR2AHTR2CHTR2BPNMTASIC3 | |
| SCHEMBL27919637 | 0.81 | TBXA2R (0.37) | HTR2AHTR2CHTR2B | |
| SCHEMBL27743677 | 0.81 | DRD2 (0.44) | KDM1A | |
| SCHEMBL27919507 | 0.81 | HTR2C (0.50) | HTR2AHTR2CHTR2BPARP10PARP1 | |
| SCHEMBL28823708 | 0.78 | CAMK2A (0.47) | HTR2AHTR2CHTR2BPARP10PARP1 | |
| SCHEMBL27901796 | 0.77 | HTR2A (0.54) | HTR2AHTR2CHTR2BPARP10PARP1 | |
| SCHEMBL27779522 | 0.77 | F2 (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL95059 | 0.76 | PRCP (0.53) | HTR2AHTR2CHTR2B | |
| SCHEMBL1799182 | 0.76 | PRCP (0.53) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113811529-A | Fibroblast activation protein inhibitor | 普拉西斯生物技术有限责任公司 | 2021-12-17 | — | — | CN | disclosed |
| CN-103108871-B | 17a-hydroxylase/c17,20-lyase inhibitors | NOVARTIS AG | 2014-09-10 | — | — | CN | disclosed |
| CN-103108871-A | 17a-hydroxylase/c17,20-lyase inhibitors | NOVARTIS AG | 2013-05-15 | — | — | CN | disclosed |
| CN-101848896-A | Isoquinolinyl and isoindolinyl derivatives as histamine-3 antagonists | WYETH CORP | 2010-09-29 | — | — | CN | disclosed |