Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258706 | 1.00 | L3MBTL1 (0.43) | L3MBTL1CYP2C19CYP2D6MEN1KMT2A | |
| SCHEMBL760418 | 0.90 | MEN1 (0.37) | L3MBTL1MEN1KMT2ANAMPTABL1 | |
| SCHEMBL7744031 | 0.88 | CCR5 (0.41) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL10128793 | 0.87 | GPR119 (0.41) | LMNAALDH1A1TSHR | |
| SCHEMBL760419 | 0.85 | GPR119 (0.36) | LMNATGM2ALDH1A1TSHR | |
| SCHEMBL8251763 | 0.76 | PSEN1 (0.60) | — | |
| SCHEMBL8051176 | 0.71 | PSEN1 (0.40) | L3MBTL1MEN1KMT2ATP53ALDH1A1 | |
| SCHEMBL265005 | 0.68 | NAMPT (0.65) | NAMPTMAPTABL1RIN1PTPN2 | |
| SCHEMBL13405090 | 0.66 | PSEN1 (0.38) | L3MBTL1MEN1KMT2ATP53PTPN1 | |
| SCHEMBL8054683 | 0.66 | PSEN1 (0.38) | L3MBTL1MEN1KMT2ATP53PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2258680-B1 | Aromatic derivatives as HIV aspartyl protease inhibitors | TAIMED BIOLOG INC (TW) | 2012-09-19 | — | — | EP | disclosed |
| EP-2258680-A2 | Aromatic derivatives as HIV aspartyl protease inhibitors | Ambrilia Biopharma Inc. (CA) | 2010-12-08 | — | — | EP | disclosed |
| EP-2258681-A2 | Aromatic Derivatives as HIV Aspartyl Protease Inhibitors | Ambrilia Biopharma Inc. (CA) | 2010-12-08 | — | — | EP | disclosed |
| US-6632816-B1 | Aromatic derivatives as HIV aspartyl protease inhibitors | PHARMACOR INC. (CA) | 2003-10-14 | — | — | US | disclosed |