Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906328 | 0.91 | MAP3K7 (0.42) | MAP3K7NTRK1NTRK2GRM5ALDH1A1 | |
| SCHEMBL2900071 | 0.77 | HTT (0.39) | MAP3K7NTRK1NTRK2GRM5ALDH1A1 | |
| SCHEMBL28776251 | 0.76 | SLC16A3 (0.39) | ALDH1A1LMNAKDM4ESLC16A3SLC16A1 | |
| SCHEMBL2919060 | 0.75 | GRM5 (0.42) | MAP3K7NTRK1NTRK2GRM5ALDH1A1 | |
| SCHEMBL27722384 | 0.74 | ALDH1A1 (0.39) | ALDH1A1LMNAKDM4EHPGDJAK2 | |
| SCHEMBL7239764 | 0.71 | NOTUM (0.46) | GRM5ALDH1A1ROCK2NOTUM | |
| SCHEMBL27742974 | 0.70 | LMNA (0.38) | ALDH1A1LMNANPBWR1KDM4EHPGD | |
| SCHEMBL3777984 | 0.70 | NTRK1 (0.59) | NTRK1NTRK2HPGDJAK2MAPK14 | |
| SCHEMBL2028690 | 0.69 | ABL1 (0.49) | MAP3K7NTRK1NTRK2ALDH1A1LMNA | |
| SCHEMBL2927010 | 0.68 | NSD2 (0.44) | GRM5ALDH1A1LMNAROCK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101878031-A | The inhibitors of kinases that is used for the treatment of myeloproliferative disease and other proliferative diseases | DECIPHERA PHARMACEUTICALS LLC | 2010-11-03 | — | — | CN | disclosed |