Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2796169 | 0.74 | HTT (0.39) | CES2CES1ALDH1A1LMNAHTT | |
| SCHEMBL27778788 | 0.71 | CYP1A2 (0.46) | KMT2AALDH1A1MAPTELANERAB9A | |
| SCHEMBL9902302 | 0.66 | HTT (0.59) | KMT2APOLBALDH1A1MAPTELANE | |
| SCHEMBL11767895 | 0.65 | CTNNB1 (0.60) | ALDH1A1MAPTELANETSHRPDE4A | |
| SCHEMBL1961466 | 0.64 | MAPT (0.55) | POLBALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL27778992 | 0.64 | MEP1B (0.40) | KMT2ACES2CES1ALDH1A1MAPT | |
| SCHEMBL12780282 | 0.63 | HIF1A (0.39) | KMT2ACES2CES1ALDH1A1MAPT | |
| SCHEMBL9044934 | 0.63 | CTNNB1 (0.57) | POLBALDH1A1MAPTELANETSHR | |
| SCHEMBL6118090 | 0.63 | LMNA (0.44) | KMT2APOLBALDH1A1MAPTRAB9A | |
| SCHEMBL17416961 | 0.62 | CES2 (0.59) | KMT2ACES2CES1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101663281-A | Amino-5- [ 4- (difluoromethoxy) phenyl ] -5-phenylimidazolidinone compounds which inhibit the beta-secretase enzyme | WYETH CORP | 2010-03-03 | — | — | CN | disclosed |