Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 5/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29945235 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL23457112 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL783254 | 0.74 | ALDH1A1 (0.48) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL9681660 | 0.74 | ESR1 (0.38) | MAPTTSHRCYP1A2 | |
| SCHEMBL10928549 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL4876931 | 0.69 | ALDH1A1 (0.46) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL28793384 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1RAPGEF4EGFRNPC1 | |
| SCHEMBL17937684 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1RAPGEF4EGFRNPC1 | |
| SCHEMBL8723541 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A | |
| SCHEMBL8722507 | 0.68 | ALDH1A1 (0.41) | ALDH1A1MAPK1RAPGEF4NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101663281-A | Amino-5- [ 4- (difluoromethoxy) phenyl ] -5-phenylimidazolidinone compounds which inhibit the beta-secretase enzyme | WYETH CORP | 2010-03-03 | — | — | CN | disclosed |