SCHEMBL27795367

SCHEMBL27795367

Cc1cc(C(=O)O)cc(C(=O)O)c1.Cc1ccc(S(=O)(=O)n2ccc3cccnc32)cc1

nearest known ligand 0.76

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.76
RAPGEF4 Q8WZA2 3/20 0.62
CYP2C19 P33261 1/20 0.62
PKM P14618 1/20 0.58
HDAC3 O15379 2/20 0.53
HDAC4 P56524 2/20 0.53
HDAC1 Q13547 2/20 0.53
HDAC7 Q8WUI4 2/20 0.53
HDAC2 Q92769 2/20 0.53
HDAC10 Q969S8 2/20 0.53
HDAC11 Q96DB2 2/20 0.53
HDAC8 Q9BY41 2/20 0.53
HDAC6 Q9UBN7 2/20 0.53
HDAC9 Q9UKV0 2/20 0.53
HDAC5 Q9UQL6 2/20 0.53
ENPP3 O14638 2/20 0.51
PTGDR2 Q9Y5Y4 1/20 0.44
HTR6 P50406 1/20 0.42
SLC22A12 Q96S37 2/20 0.41
ENPP1 P22413 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4532804 0.87 L3MBTL1 (1.00) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL1714526 0.87 L3MBTL1 (1.00) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL30365350 0.87 L3MBTL1 (1.00) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL27942418 0.86 L3MBTL1 (0.68) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL28022275 0.86 L3MBTL1 (0.64) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL28072743 0.80 L3MBTL1 (0.57) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL27958491 0.80 CYP2C19 (0.65) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL1773294 0.78 CYP2C19 (1.00) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL15175383 0.77 RAPGEF4 (1.00) L3MBTL1RAPGEF4CYP2C19PKMHDAC3
SCHEMBL28090729 0.76 MET (0.70) L3MBTL1RAPGEF4CYP2C19HTR6ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101678022-A 5-cyano-4- (pyrrolo [2,3b ] pyridin-3-yl) pyrimidine derivatives useful as protein kinase inhibitors VERTEX PHARMA 2010-03-24 CN disclosed