Sugi Predict

Sugi Predict / Compounds / SCHEMBL1773294

SCHEMBL1773294

SCHEMBL1773294

O=S(=O)(c1ccccc1)n1ccc2cccnc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CYP2C19 P33261 1/20 1.00
▸ L3MBTL1 Q9Y468 3/20 0.76
▸ PKM P14618 2/20 0.76
▸ RAPGEF4 Q8WZA2 1/20 0.63
▸ HDAC3 O15379 2/20 0.60
▸ HDAC4 P56524 2/20 0.60
▸ HDAC1 Q13547 2/20 0.60
▸ HDAC7 Q8WUI4 2/20 0.60
▸ HDAC2 Q92769 2/20 0.60
▸ HDAC10 Q969S8 2/20 0.60
▸ HDAC11 Q96DB2 2/20 0.60
▸ HDAC8 Q9BY41 2/20 0.60
▸ HDAC6 Q9UBN7 2/20 0.60
▸ HDAC9 Q9UKV0 2/20 0.60
▸ HDAC5 Q9UQL6 2/20 0.60
▸ MET P08581 1/20 0.59
▸ HTR6 P50406 8/20 0.58
▸ MEN1 O00255 2/20 0.58
▸ HTT P42858 2/20 0.58
▸ KMT2A Q03164 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20549621 0.86 CYP2C19 (0.76) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL30365350 0.86 L3MBTL1 (1.00) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL3507507 0.86 PKM (1.00) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL1714526 0.86 L3MBTL1 (1.00) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL4532804 0.86 L3MBTL1 (1.00) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL17818443 0.84 CYP2C19 (0.73) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL27958491 0.80 CYP2C19 (0.65) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL27734768 0.79 RAPGEF4 (0.65) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL27807290 0.79 CYP2C19 (0.62) CYP2C19L3MBTL1PKMRAPGEF4HDAC3
SCHEMBL21295073 0.79 MET (0.65) CYP2C19L3MBTL1PKMMETHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 151 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111454313-A Triazole glucoside derivative of 3-nitro-1-benzenesulfonyl-7-azaindole, and preparation method and application thereof 绍兴文理学院 2020-07-28 — — CN claimed
CN-119019389-B 7-Azaindole compound and synthetic method and application thereof SICHUAN UNIVERSITY (CN) 2026-05-26 — — CN disclosed
US-12559489-B2 Antagonistic small molecule compound having toll-like receptor 7/9 inhibitory function AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2026-02-24 — — US disclosed
CN-119019389-A 7-Azaindole compound and synthetic method and application thereof 四川大学 2024-11-26 — — CN disclosed
US-20230339935-A1 ANTAGONISTIC SMALL MOLECULE COMPOUND HAVING TOLL-LIKE RECEPTOR 7/9 INHIBITORY FUNCTION AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR) 2023-10-26 — — US disclosed
EP-4214199-A1 CASEIN KINASE 1 DELTA MODULATORS JANSSEN Pharmaceutica NV (BE) 2023-07-26 — — EP disclosed
CN-116490503-A Casein kinase 1 delta modulators 詹森药业有限公司 2023-07-25 — — CN disclosed
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME Halia Therapeutics, Inc. 2023-07-06 — — US disclosed
US-20230066771-A1 NUCLEAR RECEPTOR MODULATORS ABBVIE INC (US) 2023-03-02 — — US disclosed
CN-110194770-B Peptidyl arginine deiminase inhibitors and uses thereof 药捷安康(南京)科技股份有限公司 2022-08-09 — — CN disclosed
WO-2002012240-A1 DERIVATIVES OF VARIOLIN B UNIVERSIDAD DE BARCELONA (ES) 2002-02-14 — — WO disclosed
CN-1058967-C Novel pyridine compounds, processes for their preparation and pharmaceutical compositions which contain them ADIR (FR) 2000-11-29 — — CN disclosed
EP-0737685-B1 Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them ADIR (FR) 2000-07-19 — — EP disclosed
US-5763461-A ANTIPICORNAVIRAL AGENTS SANOFI (FR) 1998-06-09 — — US disclosed
US-5618821-A VIRICIDES, PICORNAVIRUS SANOFI, S.A. (FR) 1997-04-08 — — US disclosed
CN-1139111-A Novel pyridine compounds, processes for their preparation and pharmaceutical compositions which contain them ADIR (FR) 1997-01-01 — — CN disclosed
EP-0737685-A1 Pyridine derivatives, process for their preparation and pharmaceutical compositions containing them ADIR ET COMPAGNIE (FR) 1996-10-16 — — EP disclosed
WO-1995031438-A1 THERAPEUTIC PHENOXYALKYLHETEROCYCLES SANOFI WINTHROP, INC. (US) 1995-11-23 — — WO disclosed
EP-0497516-A1 Substituted pyrrolo-fused 6-membered heterocycles as angiotensin II antagonists MERCK & CO. INC. (US) 1992-08-05 — — EP disclosed
US-5124335-A Hypotensive agents, antiglaucoma agents MERCK & CO., INC. (US) 1992-06-23 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230210853-A1 TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME NEK7, NLRP3, NOD1 CYP2C19 4798/4885L3MBTL1 1661/4885PKM 1837/4885
US-12559489-B2 Antagonistic small molecule compound having toll-like receptor 7/9 inhibitory function TLR9, TLR7, TLR1 CYP2C19 2990/4885L3MBTL1 3934/4885PKM 1203/4885
US-20230339935-A1 ANTAGONISTIC SMALL MOLECULE COMPOUND HAVING TOLL-LIKE RECEPTOR 7/9 INHIBITORY FUNCTION TLR9, TLR7, TLR1 CYP2C19 4339/4885L3MBTL1 2725/4885PKM 3018/4885
US-20230066771-A1 NUCLEAR RECEPTOR MODULATORS NR1I2, NR1H2, NR5A2 CYP2C19 325/4885L3MBTL1 4815/4885PKM 1951/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.