Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779965 | 0.88 | ROCK2 (0.46) | SMN1; SMN2LMNACCR2GAATDP1 | |
| SCHEMBL2336929 | 0.88 | MRGPRX4 (0.54) | MRGPRX4SMN1; SMN2LMNACCR2GAA | |
| SCHEMBL2783223 | 0.85 | CCR2 (0.47) | SMN1; SMN2LMNACCR2ROCK2 | |
| SCHEMBL2782132 | 0.84 | MAPK8 (0.53) | MRGPRX4LMNATDP1KDM4EHTT | |
| SCHEMBL2332795 | 0.83 | TP53 (0.52) | SMN1; SMN2LMNACCR2GAATDP1 | |
| SCHEMBL2336930 | 0.82 | LMNA (0.47) | SMN1; SMN2LMNACCR2GAATDP1 | |
| SCHEMBL2781998 | 0.82 | MRGPRX4 (0.56) | MRGPRX4TDP1 | |
| SCHEMBL2780412 | 0.81 | UGCG (0.49) | MRGPRX4SMN1; SMN2LMNAGAAKDM4E | |
| SCHEMBL7431657 | 0.81 | CCR2 (0.50) | SMN1; SMN2LMNACCR2GAATDP1 | |
| SCHEMBL2335696 | 0.81 | GPBAR1 (0.60) | MRGPRX4SMN1; SMN2LMNACCR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010091104-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EXELIXIS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |