Guanosine

Guanosine

SCHEMBL27797461

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=P(O)(O)OP(=O)(O)O.O=P(O)(O)OP(=O)(O)O.O=P(O)(O)OP(=O)(O)O

nearest known ligand 0.70

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Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.70
TGM2 P21980 1/20 0.67
HPGD P15428 1/20 0.66
HINT1 P49773 4/20 0.62
KRAS P01116 4/20 0.61
FUT5 Q11128 1/20 0.60
IMPDH2 P12268 5/20 0.59
IMPDH1 P20839 1/20 0.59
GSK3A P49840 2/20 0.59
RPS6KA3 P51812 2/20 0.59
MAPK14 Q16539 2/20 0.59
P2RY2 P41231 1/20 0.57
P2RY4 P51582 1/20 0.57
P2RY6 Q15077 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL37404 1.00 NT5E (0.70) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL22134208 0.99 NT5E (0.69) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL9827513 0.97 NT5E (0.69) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL6066347 0.97 NT5E (0.69) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL30589987 0.97 NT5E (0.69) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL19211836 0.96 NT5E (0.68) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL4625995 0.96 NT5E (0.68) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL30125158 0.96 NT5E (0.68) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL17845812 0.95 HINT1 (0.64) NT5ETGM2HPGDHINT1KRAS
Guanosine SCHEMBL27216236 0.95 HINT1 (0.64) NT5ETGM2HPGDHINT1KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101849020-A The method and composition of riboswitch and use riboswitch UNIV YALE 2010-09-29 CN disclosed