Guanosine

Guanosine

SCHEMBL6066347

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=P(O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.69
TGM2 P21980 1/20 0.69
HPGD P15428 1/20 0.64
KRAS P01116 4/20 0.62
FUT5 Q11128 1/20 0.61
HINT1 P49773 3/20 0.61
IMPDH2 P12268 5/20 0.58
P2RY2 P41231 2/20 0.58
P2RY4 P51582 1/20 0.58
P2RY6 Q15077 1/20 0.58
IMPDH1 P20839 1/20 0.58
GSK3A P49840 2/20 0.58
RPS6KA3 P51812 2/20 0.58
MAPK14 Q16539 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL30589987 1.00 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL9827513 1.00 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL19211836 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL30125158 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL4625995 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL27797461 0.97 NT5E (0.70) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL37404 0.97 NT5E (0.70) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL4410882 0.96 TGM2 (0.65) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL22134208 0.96 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL29046528 0.96 TGM2 (0.64) NT5ETGM2HPGDKRASFUT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105973890-B A kind of screening technique of active substance of plant 西南大学 2018-11-13 CN claimed
CN-106086183-A A kind of based on rich guanine DNA sensitization Tb3+the MicroRNA detection method of fluorescence 南昌大学 2016-11-09 CN claimed
US-12600958-B2 Methods and compositions for manufacturing polynucleotides PRIMROSE BIO, INC. (US) 2026-04-14 US disclosed
US-20230076421-A1 METHODS AND COMPOSITIONS FOR MANUFACTURING POLYNUCLEOTIDES PRIMORDIAL GENETICS INC. 2023-03-09 US disclosed
WO-2022233255-A1 PREPARATION AND COMPOSITION OF NOVEL 4(3H)-QUINAZOLINONE ANALOGUE/CYCLIC DINUCLEOTIDE CGAMP CO-LOADED LIPOSOME AND APPLICATION THEREOF IN ANTITUMOR DRUGS 杭州星鳌生物科技有限公司 2022-11-10 WO disclosed
CN-110093284-A Method for improving protein synthesis efficiency in cell 康码(上海)生物科技有限公司 2019-08-06 CN disclosed
CN-109971783-A In-vitro protein synthesis system, kit and preparation method thereof 康码(上海)生物科技有限公司 2019-07-05 CN disclosed
CN-108949801-B A method of by knocking out nucleic acid enzyme system to regulate and control external biological synthesizing activity 康码(上海)生物科技有限公司 2019-06-14 CN disclosed
CN-109837293-A A kind of series connection DNA element that can enhance protein synthesis efficiency 康码(上海)生物科技有限公司 2019-06-04 CN disclosed
CN-109071618-A MUTANT PORE 牛津纳米孔技术公司 2018-12-21 CN disclosed
CN-108398397-A Detection system of nucleoside triphosphate compound and application thereof 中国科学院理化技术研究所 2018-08-14 CN disclosed
CN-101557726-A High-potency sweetener composition with Rubisco protein, Rubiscolin, Rubiscolin derivatives, ACE inhibitory peptides, and combinations thereof, and compositions sweetened therewith COCA COLA CO (US) 2009-10-14 CN disclosed
CN-101553132-A High-potency sweetener compositions with phytoestrogens and compositions sweetened therewith COCA COLA CO (US) 2009-10-07 CN disclosed
CN-101365348-A High-potency sweetener composition with vitamin and compositions sweetened therewith COCA COLA CO (US) 2009-02-11 CN disclosed
CN-101340826-A High-potency sweetener composition with fatty acid and compositions sweetened therewith COCA COLA CO (US) 2009-01-07 CN disclosed
CN-101309601-A High-potency sweetener composition with an anti-inflammatory agent and compositions sweetened therewith COCA COLA CO (US) 2008-11-19 CN disclosed
CN-101309598-A Calcium-containing high-potency sweetener composition and compositions sweetened therewith COCA COLA CO (US) 2008-11-19 CN disclosed
CN-101000348-A Method of GTP combining experimental signal window of enlarging GPCR tagging SHANGHAI TARGET MEDICINE CO LT (CN) 2007-07-18 CN disclosed
WO-2006003638-A2 NOVEL METHOD FOR LABELING NUCLEIC ACID IN A SEQUENCE-SPECIFIC MANNER, AND METHOD FOR DETECTING NUCLEIC ACID USING THE SAME NATIONAL INSTITUTE OF AGROBIOLOGICAL SCIENCES (JP) 2006-01-12 WO disclosed
US-6453064-B1 Common structure extraction apparatus FUJITSU LIMITED (JP) 2002-09-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12600958-B2 Methods and compositions for manufacturing polynucleotides MED25, RNGTT, NSUN2 NT5E 132/4885TGM2 1375/4885HPGD 3276/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.