Guanosine

Guanosine

SCHEMBL30589987

Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.Nc1nc2c(ncn2[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c(=O)[nH]1.O=P(O)(O)OP(=O)(O)OP(=O)(O)O

nearest known ligand 0.69

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ NT5E P21589 1/20 0.69
▸ TGM2 P21980 1/20 0.69
▸ HPGD P15428 1/20 0.64
▸ KRAS P01116 4/20 0.62
▸ FUT5 Q11128 1/20 0.61
▸ HINT1 P49773 3/20 0.61
▸ IMPDH2 P12268 5/20 0.58
▸ P2RY2 P41231 2/20 0.58
▸ P2RY4 P51582 1/20 0.58
▸ P2RY6 Q15077 1/20 0.58
▸ IMPDH1 P20839 1/20 0.58
▸ GSK3A P49840 2/20 0.58
▸ RPS6KA3 P51812 2/20 0.58
▸ MAPK14 Q16539 2/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanosine SCHEMBL9827513 1.00 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL6066347 1.00 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL19211836 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL30125158 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL4625995 0.99 NT5E (0.68) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL27797461 0.97 NT5E (0.70) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL37404 0.97 NT5E (0.70) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL4410882 0.96 TGM2 (0.65) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL22134208 0.96 NT5E (0.69) NT5ETGM2HPGDKRASFUT5
Guanosine SCHEMBL29046528 0.96 TGM2 (0.64) NT5ETGM2HPGDKRASFUT5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250213729-A1 METHOD TO STIMULATE REGENERATION OF RETINAL GANGLION CELLS UNIVERSITY OF WASHINGTON (US) 2025-07-03 — — US disclosed
EP-4504225-A2 METHOD TO STIMULATE REGENERATION OF RETINAL GANGLION CELLS University of Washington (US) 2025-02-12 — — EP disclosed
WO-2023192994-A2 METHOD TO STIMULATE REGENERATION OF RETINAL GANGLION CELLS UNIVERSITY OF WASHINGTON (US) 2023-10-05 — — WO disclosed
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