Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 8/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 8/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 8/20 | 0.55 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2781731 | 0.86 | ADRA2A (0.54) | ADRA2AADRA2BADRA2CPLAULMNA | |
| SCHEMBL2782078 | 0.85 | ADRA2A (0.51) | ADRA2AADRA2BADRA2CPLAULMNA | |
| SCHEMBL4629712 | 0.84 | ADRA2A (0.52) | ADRA2AADRA2BADRA2CPLAUNPC1 | |
| SCHEMBL2777858 | 0.81 | ADRA2A (0.49) | ADRA2AADRA2BADRA2CPLAUNPC1 | |
| SCHEMBL2779380 | 0.80 | ADRA2A (0.48) | ADRA2AADRA2BADRA2CPLAUNPC1 | |
| SCHEMBL2780849 | 0.75 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CPLAUSIGMAR1 | |
| SCHEMBL2780340 | 0.72 | ADRA2A (0.47) | ADRA2AADRA2BADRA2CPLAULMNA | |
| SCHEMBL2780959 | 0.71 | LMNA (0.49) | ADRA2AADRA2BADRA2CPLAULMNA | |
| SCHEMBL2782802 | 0.71 | NPC1 (0.42) | ADRA2AADRA2BADRA2CPLAULMNA | |
| SCHEMBL2781085 | 0.71 | MAPK1 (0.46) | ADRA2AADRA2BADRA2CPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296697-B2 | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors | ABBOTT LABORATORIES (US) | 2016-03-29 | — | — | US | claimed |
| US-9296697-B2 | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors | ABBOTT LABORATORIES (US) | 2016-03-29 | — | — | US | disclosed |
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | HTR5A, HTR2C, HTR1E | ADRA2A 78/4885ADRA2B 67/4885ADRA2C 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.