Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL29670981 | 1.00 | HIF1A (0.43) | HIF1AACE2CSNK1EALDH1A1MEN1 | |
| Bromide SCHEMBL28576198 | 1.00 | HIF1A (0.43) | HIF1AACE2CSNK1EALDH1A1MEN1 | |
| Bromide SCHEMBL11781944 | 0.95 | HIF1A (0.45) | HIF1AACE2CSNK1EALDH1A1MEN1 | |
| Bromide SCHEMBL11703906 | 0.82 | LMNA (0.45) | HIF1AALDH1A1MEN1KMT2AMMP9 | |
| Bromide SCHEMBL11703048 | 0.82 | LMNA (0.45) | HIF1AALDH1A1MEN1KMT2AMMP9 | |
| Bromide SCHEMBL678415 | 0.81 | HIF1A (0.56) | HIF1ACSNK1EALDH1A1DNM1CYP1A2 | |
| Bromide SCHEMBL8775234 | 0.81 | HIF1A (0.56) | HIF1ACSNK1EALDH1A1DNM1CYP1A2 | |
| Bromide SCHEMBL286882 | 0.81 | HIF1A (0.56) | HIF1ACSNK1EALDH1A1DNM1CYP1A2 | |
| Bromide SCHEMBL7759526 | 0.81 | HIF1A (0.56) | HIF1ACSNK1EALDH1A1DNM1CYP1A2 | |
| Bromide SCHEMBL2979400 | 0.81 | HIF1A (0.56) | HIF1ACSNK1EALDH1A1DNM1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101686979-A | The urea modulators that the heteroaryl of fatty acid amide hydrolase replaces | JANSSEN PHARMACEUTICA NV | 2010-03-31 | — | — | CN | disclosed |