Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.42 |
| ▸ | CBFB | Q13951 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22365585 | 0.84 | ROCK2 (0.47) | POLBGRM2HSD11B1ELANEMEN1 | |
| SCHEMBL8814165 | 0.81 | ALDH1A1 (0.44) | POLBMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL14140972 | 0.78 | POLB (0.53) | POLBGRM2HSD11B1PKMNPC1 | |
| SCHEMBL14140969 | 0.78 | POLB (0.53) | POLBGRM2HSD11B1PKMNPC1 | |
| SCHEMBL28439668 | 0.77 | POLB (0.51) | POLBGRM2HSD11B1SMN1; SMN2PKM | |
| SCHEMBL28950551 | 0.77 | POLB (0.51) | POLBGRM2HSD11B1PKMNPC1 | |
| SCHEMBL28950554 | 0.77 | POLB (0.51) | POLBGRM2HSD11B1PKMNPC1 | |
| SCHEMBL28428120 | 0.77 | SOAT1 (0.58) | GRM2MEN1TSHRKMT2AMAPT | |
| SCHEMBL2800406 | 0.75 | POLB (0.50) | POLBGRM2HSD11B1MEN1KMT2A | |
| SCHEMBL8494181 | 0.75 | POLB (0.50) | POLBGRM2HSD11B1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101747250-B | Method for preparing 4 - acyloxo heterocyclic ketone compounds | SHANGHAI INST PHARM INDUSTRY | 2012-09-05 | — | — | CN | disclosed |
| CN-101747250-A | Method for preparing 4 - acyloxo heterocyclic ketone compounds | SHANGHAI INST PHARM INDUSTRY | 2010-06-23 | — | — | CN | disclosed |