Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28790701 | 0.90 | HTR1A (0.42) | DRD4DRD2DRD3MTNR1AKDM4E | |
| SCHEMBL3699696 | 0.90 | PDPK1 (0.41) | DRD4DRD2DRD3MTNR1AKDM4E | |
| SCHEMBL27807485 | 0.90 | TRPV1 (0.48) | DRD4DRD2DRD3PDPK1TRPV1 | |
| SCHEMBL3699011 | 0.89 | ALDH1A1 (0.45) | DRD4DRD2DRD3MTNR1AKDM4E | |
| SCHEMBL3707612 | 0.89 | KDM4E (0.45) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3702661 | 0.89 | PDPK1 (0.41) | DRD4DRD2DRD3MTNR1AKDM4E | |
| Hydrochloric Acid SCHEMBL3706766 | 0.89 | ALDH1A1 (0.44) | DRD4DRD2DRD3MTNR1AKDM4E | |
| SCHEMBL27807533 | 0.88 | BRAF (0.36) | ALDH1A1TRPV1THRATHRBLMNA | |
| SCHEMBL3706989 | 0.88 | PTGER3 (0.47) | DRD4DRD2DRD3MTNR1AKDM4E | |
| SCHEMBL3703390 | 0.88 | DRD2 (0.45) | DRD4DRD2DRD3MTNR1AGPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102066372-A | 5, 6-membered heteroaryl bicyclic compounds containing a urea group as kinase inhibitors | ASCEPION PHARMACEUTICALS INC | 2011-05-18 | — | — | CN | claimed |
| CN-102066372-B | 5, 6-membered heteroaryl bicyclic compounds containing a urea group as kinase inhibitors | ASCEPION PHARMACEUTICALS INC | 2014-09-17 | — | — | CN | disclosed |
| CN-102066372-A | 5, 6-membered heteroaryl bicyclic compounds containing a urea group as kinase inhibitors | ASCEPION PHARMACEUTICALS INC | 2011-05-18 | — | — | CN | disclosed |