Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.49 |
| ▸ | BTK | Q06187 | 8/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 3/20 | 0.36 |
| ▸ | GFRA3 | O60609 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785768 | 0.88 | EGFR (0.47) | EGFRBTKROCK2IGF1RGFRA3 | |
| SCHEMBL27785694 | 0.77 | EGFR (0.41) | EGFRBTKIGF1RGALR2 | |
| SCHEMBL27785763 | 0.76 | EGFR (0.41) | EGFRBTKIGF1RITK | |
| SCHEMBL27785807 | 0.74 | EGFR (0.39) | EGFRBTK | |
| SCHEMBL27785754 | 0.72 | EGFR (0.41) | EGFRBTK | |
| SCHEMBL27785729 | 0.71 | SYK (0.53) | EGFRGALR2 | |
| SCHEMBL3646162 | 0.70 | EGFR (0.50) | EGFRBTKITK | |
| SCHEMBL3650240 | 0.70 | EGFR (0.47) | EGFRBTKROCK2GFRA3RET | |
| SCHEMBL3651562 | 0.70 | NLRP3 (0.49) | EGFRBTK | |
| SCHEMBL3651441 | 0.70 | EGFR (0.46) | EGFRBTKGFRA3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | claimed |
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |