Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | BTK | Q06187 | 5/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3650361 | 0.88 | CSF1R (0.41) | EGFRBTKAXLCSF1RDYRK1A | |
| SCHEMBL3652871 | 0.88 | LTA4H (0.40) | EGFRBTKAXLCSF1RDYRK1A | |
| SCHEMBL13472146 | 0.78 | CSF1R (0.42) | AXLCSF1RHTR2AMCHR1EPHX2 | |
| SCHEMBL3650367 | 0.78 | EGFR (0.39) | EGFRBTKAXLDYRK1ACNR2 | |
| SCHEMBL13472149 | 0.78 | CSF1R (0.43) | BTKAXLCSF1RDYRK1AHTR2A | |
| SCHEMBL3644492 | 0.77 | LTA4H (0.49) | EGFRAXLMCHR1JAK3DRD2 | |
| SCHEMBL3646162 | 0.77 | EGFR (0.50) | EGFRBTKHTR1AHTR7ITK | |
| SCHEMBL27807597 | 0.76 | EGFR (0.49) | EGFRBTKITKIGF1R | |
| SCHEMBL3650235 | 0.75 | LTA4H (0.49) | EGFRBTKHTR1AHTR7DRD2 | |
| SCHEMBL3650207 | 0.73 | GPR6 (0.41) | EGFRBTKCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101784530-A | 5- (4- (haloalkoxy) phenyl) pyrimidine-2-amine compounds and compositions as kinase inhibitors | IRM LLC | 2010-07-21 | — | — | CN | disclosed |