Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
| ▸ | GAK | O14976 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786088 | 0.90 | CRHR1 (0.33) | SYKPDE4DNPY1RNPY5RGABRG2 | |
| SCHEMBL27785971 | 0.88 | GABRG2 (0.33) | ABCG2PIK3CAGABRG2GABRB3GABRA2 | |
| SCHEMBL27786013 | 0.87 | PIK3CA (0.33) | PIK3CASYKNPY1RNPY5RGABRG2 | |
| SCHEMBL27807912 | 0.86 | CD274 (0.36) | CD274ABCG2ALOX5APFEN1SYK | |
| SCHEMBL27785979 | 0.86 | GABRA1 (0.42) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27785952 | 0.86 | PIK3CA (0.40) | CD274PIK3CAHRH4ABL1 | |
| SCHEMBL27786017 | 0.85 | ALK (0.35) | NPY1RNPY5RGABRG2GABRB3GABRA2 | |
| SCHEMBL28784318 | 0.85 | SSTR2 (0.35) | PIK3CAGABRG2GABRB3GABRA2HRH4 | |
| SCHEMBL27785951 | 0.84 | CRHR1 (0.41) | PDE4DNPY1RNPY5RGABRG2GABRB3 | |
| SCHEMBL27785999 | 0.83 | HRH4 (0.32) | PIK3CAGABRG2GABRB3GABRA2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |