Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KIF5B | P33176 | 1/20 | 0.31 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786088 | 0.97 | CRHR1 (0.33) | SYKGABRG2GABRB3GABRA2CRHR1 | |
| SCHEMBL27807908 | 0.87 | CD274 (0.34) | PIK3CASYKGABRG2GABRB3GABRA2 | |
| SCHEMBL27786149 | 0.86 | PIK3CA (0.42) | PIK3CAHRH3GABRG2GABRB3GABRA2 | |
| SCHEMBL27786002 | 0.85 | PIK3CA (0.33) | PIK3CAHRH3GABRG2GABRB3GABRA2 | |
| SCHEMBL27785952 | 0.83 | PIK3CA (0.40) | PIK3CA | |
| SCHEMBL27785951 | 0.82 | CRHR1 (0.41) | GABRG2GABRB3GABRA2CRHR1NPY1R | |
| SCHEMBL27785948 | 0.82 | GABRG2 (0.34) | PIK3CAGABRG2GABRB3GABRA2NPY1R | |
| SCHEMBL27785963 | 0.82 | SSTR2 (0.34) | PIK3CAKCNH2HRH3GABRG2GABRB3 | |
| SCHEMBL27786270 | 0.82 | GABRG2 (0.41) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807904 | 0.82 | PIK3CA (0.42) | PIK3CAAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |