Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 10/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 10/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 10/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | ERN1 | O75460 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807995 | 0.92 | GABRG2 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27808014 | 0.91 | GABRA1 (0.47) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785975 | 0.89 | GABRA1 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807912 | 0.88 | CD274 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27786019 | 0.87 | GABRG2 (0.47) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785960 | 0.85 | PIK3CA (0.35) | GABRG2GABRB3GABRA2GABRA5GABRA3 | |
| SCHEMBL27786151 | 0.84 | BRD9 (0.37) | GABRG2GABRB3GABRA2ERN1 | |
| SCHEMBL27807955 | 0.84 | SSTR2 (0.33) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785938 | 0.80 | BTK (0.47) | GABRG2GABRB3GABRA2 | |
| SCHEMBL27807959 | 0.80 | HRH4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |