Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 14/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 14/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 14/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27786138 | 0.88 | GABRG2 (0.42) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27785938 | 0.88 | BTK (0.47) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27807917 | 0.87 | GABRG2 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807915 | 0.87 | GABRG2 (0.41) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785942 | 0.86 | GABRG2 (0.42) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27807958 | 0.85 | GABRG2 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27786270 | 0.84 | GABRG2 (0.41) | GABRG2GABRB3GABRA2LCKBTK | |
| SCHEMBL27785960 | 0.84 | PIK3CA (0.35) | GABRG2GABRB3GABRA2BTKGABRA5 | |
| SCHEMBL27807995 | 0.83 | GABRG2 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785975 | 0.82 | GABRA1 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |