Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 6/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27807917 | 0.92 | GABRG2 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807907 | 0.89 | ALK (0.35) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807932 | 0.87 | GABRG2 (0.41) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27808014 | 0.87 | GABRA1 (0.47) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27786017 | 0.86 | ALK (0.35) | GABRG2GABRB3GABRA2KCNH2CRHR1 | |
| SCHEMBL27807912 | 0.85 | CD274 (0.36) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27785975 | 0.85 | GABRA1 (0.34) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27807955 | 0.84 | SSTR2 (0.33) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27786019 | 0.83 | GABRG2 (0.47) | GABRG2GABRB3GABRA2GABRA1GABRA5 | |
| SCHEMBL27786151 | 0.82 | BRD9 (0.37) | GABRG2GABRB3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | claimed |
| CN-101778849-A | Fused quinoline derivatives useful as gaba modulators | ASTRAZENECA AB | 2010-07-14 | — | — | CN | disclosed |