Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | BRD2 | P25440 | 1/20 | 0.30 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667596 | 0.80 | MEN1 (0.43) | CHRM2PDCD1CD274KDM4EPOLB | |
| SCHEMBL3664072 | 0.78 | SCN8A (0.46) | CHRM2PDCD1CD274SCN8AKDM4E | |
| SCHEMBL3666063 | 0.71 | SMN1; SMN2 (0.51) | PDCD1CD274ALDH1A1KMT2AMEN1 | |
| SCHEMBL2751054 | 0.71 | NPC1 (0.37) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL3666546 | 0.70 | PRMT6 (0.48) | PDCD1CD274SCN8ASMN1; SMN2 | |
| SCHEMBL5769664 | 0.65 | CHRM2 (0.73) | CHRM2SCN8AKDM4EALDH1A1KMT2A | |
| SCHEMBL13778418 | 0.64 | HRH4 (0.46) | CHRM2PDCD1CD274SCN8AKDM4E | |
| SCHEMBL3668376 | 0.63 | KIF11 (0.32) | — | |
| SCHEMBL3663742 | 0.63 | ADRB2 (0.42) | KDM4ECHEK1 | |
| SCHEMBL4172134 | 0.63 | KIF11 (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101970435-B | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2014-07-02 | — | — | CN | claimed |
| CN-101970435-A | Pyrrolopyrimidines and pyrrolopyridines | NOVARTIS AG | 2011-02-09 | — | — | CN | claimed |