Urea

Urea

SCHEMBL27809446

NC(N)=O.O=c1cc[nH]c(=O)n1-c1ccccc1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GSK3A P49840 5/20 0.46
GSK3B P49841 5/20 0.46
GAA P10253 1/20 0.46
ALDH1A1 P00352 5/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 2/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP1A2 P05177 1/20 0.36
CYP2C19 P33261 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
MAPK1 P28482 1/20 0.36
CSNK2A1 P68400 4/20 0.36
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.35
NPC1 O15118 1/20 0.35
THRB P10828 1/20 0.35
HPGD P15428 1/20 0.35
RECQL P46063 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL45000 0.91 GSK3A (0.54) GSK3AGSK3BGAAALDH1A1LMNA
SCHEMBL7522262 0.81 PARP1 (0.48) GAAALDH1A1MAPTCSNK2A1KMT2A
SCHEMBL30227813 0.73 MAPT (0.41) GSK3AGSK3BALDH1A1LMNAMAPT
SCHEMBL5325747 0.73 F2 (0.47) GSK3AGSK3BALDH1A1LMNAMAPT
SCHEMBL712191 0.73 ALDH1A1 (0.49) GSK3AGSK3BGAAALDH1A1LMNA
SCHEMBL22679805 0.71 JAK2 (0.43) GSK3AGSK3BGAAALDH1A1LMNA
SCHEMBL7133475 0.71 FAAH (0.46) GSK3AGSK3BGAAALDH1A1LMNA
SCHEMBL6519756 0.71 ALDH1A1 (0.38) GAAALDH1A1LMNAMAPTNPSR1
SCHEMBL5930792 0.70 CYP2C19 (0.55) GSK3AGSK3BGAAALDH1A1MAPT
SCHEMBL8026285 0.70 PDPK1 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104222135-B Stable insecticide compositions 美国陶氏益农公司 2017-04-26 CN disclosed
CN-101535263-B Polysubstituted pyridyl sulfoximines and their use as pesticides DOW AGROSCIENCES LLC 2012-10-31 CN disclosed
CN-102633712-A Insecticidal n-substituted (heteroaryl)alkyl sulfilmines DOW AGROSCIENCES LLC 2012-08-15 CN disclosed
CN-101535261-B Insecticidal N-substituted (heteroaryl) alkyl sulfilimines DOW AGROSCIENCES LLC 2012-06-20 CN disclosed
CN-101541750-B Insecticidal N-substituted (heteroaryl) cycloalkyl sulfoximines DOW AGROSCIENCES LLC (US) 2011-11-30 CN disclosed
CN-102066336-A 2- (substituted phenyl) -6-hydroxy or alkoxy-5-substituted-pyrimidine-4-carboxylic acid esters and their use as herbicides DOW AGROSCIENCES LLC (US) 2011-05-18 CN disclosed
CN-101977900-A 5-fluoro pyrimidine derivatives DOW AGROSCIENCES LLC (US) 2011-02-16 CN disclosed
CN-101784194-A Synergistic herbicidal compositions containing substituted phenoxyalkanoic acid derivatives and glyphosate derivatives DOW AGROSCIENCES LLC 2010-07-21 CN disclosed