Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621703 | 0.91 | HPGD (0.36) | HRH2MAPTTP53RORCCASP3 | |
| SCHEMBL2781073 | 0.85 | LMNA (0.32) | LMNAALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL2782266 | 0.82 | BRD4 (0.41) | HRH2MAPTCASP3LMNAALDH1A1 | |
| SCHEMBL620435 | 0.81 | NR1H2 (0.36) | RORCCYP2C9CYP2C19 | |
| SCHEMBL2784294 | 0.81 | LMNA (0.34) | HRH2MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2784968 | 0.79 | IKBKB (0.37) | LMNAALDH1A1SMN1; SMN2ELANE | |
| SCHEMBL10211420 | 0.79 | RORC (0.37) | MAPTRORC | |
| SCHEMBL2784293 | 0.79 | LMNA (0.34) | HRH2MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2782280 | 0.79 | HRH2 (0.33) | HRH2MEN1KMT2ARXFP1 | |
| SCHEMBL2785428 | 0.79 | LMNA (0.36) | HRH2MAPTLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139322-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | Smithkline Beecham Corporation (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118724-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |