Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2782201 | 0.79 | HRH2 (0.34) | HRH2MEN1KMT2ARXFP1 | |
| SCHEMBL620741 | 0.78 | IKBKB (0.44) | — | |
| SCHEMBL621063 | 0.73 | IKBKB (0.54) | — | |
| SCHEMBL10211420 | 0.73 | RORC (0.37) | — | |
| SCHEMBL621703 | 0.70 | HPGD (0.36) | HRH2MEN1KMT2A | |
| SCHEMBL2782266 | 0.69 | BRD4 (0.41) | HRH2 | |
| SCHEMBL2781288 | 0.68 | OPRK1 (0.32) | MEN1KMT2A | |
| SCHEMBL2783700 | 0.67 | IKBKB (0.33) | MEN1KMT2ARXFP1 | |
| SCHEMBL2784293 | 0.66 | LMNA (0.34) | HRH2MEN1KMT2A | |
| SCHEMBL2781291 | 0.66 | OPRK1 (0.32) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139322-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | Smithkline Beecham Corporation (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008118724-A1 | INDOLE CARBOXAMIDES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |