Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27828533 | 0.86 | ALDH1A1 (0.52) | ALDH1A1MRGPRX4LRRK2PTGER1 | |
| SCHEMBL27841440 | 0.84 | PTGDR2 (0.48) | MRGPRX4PPARGPTGER1LMNAMAPT | |
| SCHEMBL27841439 | 0.83 | BRD4 (0.43) | BRD4MRGPRX4PPARGPTGER1LMNA | |
| SCHEMBL2175029 | 0.82 | LMNA (0.43) | BRD4MRGPRX4LRRK2PPARGPTGER1 | |
| SCHEMBL2172046 | 0.82 | LIPE (0.41) | MRGPRX4LRRK2PPARGPTGER1LMNA | |
| SCHEMBL29230634 | 0.82 | KMT2A (0.49) | ALDH1A1MRGPRX4PTGER1MEN1KMT2A | |
| SCHEMBL31667762 | 0.80 | PTGER1 (0.56) | MRGPRX4PTGER1MEN1KMT2A | |
| SCHEMBL2172852 | 0.80 | L3MBTL1 (0.41) | MRGPRX4PTGER1MEN1KMT2ALMNA | |
| SCHEMBL28789765 | 0.79 | ALDH1A1 (0.44) | ALDH1A1MIFMEN1KMT2ALMNA | |
| SCHEMBL27847218 | 0.79 | ALDH1A1 (0.47) | ALDH1A1BRD4MRGPRX4MIFPTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102216265-A | Naphthylacetic acid | HOFFMANN LA ROCHE | 2011-10-12 | — | — | CN | disclosed |
| CN-102216273-A | Naphthylacetic acids used as crth2 antagonists or partial agonists | HOFFMANN LA ROCHE (CH) | 2011-10-12 | — | — | CN | disclosed |