Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28786467 | 0.82 | KDM5C (0.41) | KMT2AKDM5CKDM4COPRD1 | |
| SCHEMBL28786528 | 0.77 | LMNA (0.45) | F10 | |
| SCHEMBL27804129 | 0.77 | MAPK1 (0.60) | F10MAPK1KMT2ABTKP2RX7 | |
| SCHEMBL3396609 | 0.76 | PIK3CD (0.41) | F10PRMT5WDR77KMT2AKDM5C | |
| SCHEMBL27915879 | 0.74 | P2RX7 (0.34) | PRMT5WDR77MAPK1KMT2AKDM5C | |
| SCHEMBL3396399 | 0.69 | LMNA (0.51) | KMT2AKDM5CKDM4C | |
| SCHEMBL28790341 | 0.68 | L3MBTL1 (0.43) | OPRD1 | |
| SCHEMBL28237788 | 0.67 | GFER (0.41) | KMT2AP2RX7 | |
| SCHEMBL14896745 | 0.67 | CXCR4 (0.50) | KMT2AKDM5CKDM4C | |
| SCHEMBL27591590 | 0.67 | F10 (0.54) | F10CASP1CASP3CASP9CASP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101981036-A | Pyrrolo [2, 3-D] pyridines and use thereof as tyrosine kinase inhibitors | NOVARTIS AG | 2011-02-23 | — | — | CN | disclosed |