Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 9/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.37 |
| ▸ | CDC25A | P30304 | 1/20 | 0.37 |
| ▸ | CDC25B | P30305 | 1/20 | 0.37 |
| ▸ | PTEN | P60484 | 1/20 | 0.37 |
| ▸ | PTPMT1 | Q8WUK0 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297817 | 0.90 | KEAP1 (0.52) | KEAP1CA1CA2FFAR1NPSR1 | |
| SCHEMBL1510393 | 0.81 | KEAP1 (0.44) | KEAP1CA1CA2FFAR1NPSR1 | |
| SCHEMBL1510335 | 0.79 | KEAP1 (0.45) | KEAP1CA1CA2FFAR1NPSR1 | |
| SCHEMBL1510085 | 0.78 | FFAR1 (0.45) | KEAP1CA1CA2FFAR1NPSR1 | |
| SCHEMBL1510103 | 0.78 | FFAR1 (0.47) | KEAP1CA1CA2FFAR1NPSR1 | |
| SCHEMBL296896 | 0.77 | MAPT (0.55) | — | |
| SCHEMBL27972897 | 0.77 | LOXL2 (0.36) | CA1CA2 | |
| SCHEMBL31273986 | 0.76 | KEAP1 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL2016247 | 0.76 | KEAP1 (0.61) | KEAP1FFAR1PTPRBCDC25ACDC25B | |
| SCHEMBL5670212 | 0.75 | KEAP1 (0.64) | KEAP1CA1CA2FFAR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056897-B | Sulfonamide compound and application thereof | ASAHI KASEI PHARMA CORP | 2014-05-07 | — | — | CN | disclosed |
| CN-102056897-A | Sulfonamide compound and application thereof | ASAHI KASEI PHARMA CORP | 2011-05-11 | — | — | CN | disclosed |