Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 13/20 | 0.53 |
| ▸ | BCHE | P06276 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 5/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.53 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.53 |
| ▸ | RECQL | P46063 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | THPO | P40225 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4629157 | 0.85 | KDM4E (0.67) | ALDH1A1MAPTCHRM2BCHEACHE | |
| SCHEMBL8356889 | 0.80 | TSHR (0.56) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL3866918 | 0.80 | L3MBTL1 (0.66) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL5695121 | 0.78 | ALDH1A1 (0.79) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL2090430 | 0.76 | IDO1 (0.53) | ALDH1A1MAPTGAACHRM2CHRM1 | |
| SCHEMBL22838152 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL418619 | 0.76 | ALDH1A1 (0.66) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL4573475 | 0.75 | ALDH1A1 (0.63) | ALDH1A1MAPTGAACHRM2BCHE | |
| SCHEMBL19091168 | 0.75 | ALDH1A1 (0.63) | ALDH1A1MAPTGAACHRM2BCHE | |
| Hydrochloric Acid SCHEMBL7876474 | 0.75 | MAPT (0.69) | ALDH1A1MAPTGAACHRM2BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296697-B2 | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors | ABBOTT LABORATORIES (US) | 2016-03-29 | — | — | US | disclosed |
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-07-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | HTR5A, HTR2C, HTR1E | ALDH1A1 1066/4885MAPT 131/4885GAA 932/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.