Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.56 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.55 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.55 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | USP8 | P40818 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1959447 | 0.86 | CYP11B2 (0.53) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL27832171 | 0.85 | GRM5 (0.62) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL6677484 | 0.82 | ALDH1A1 (0.50) | CHRNB2CHRNA5CHRNA4MIFCYP19A1 | |
| SCHEMBL27832176 | 0.81 | MIF (0.63) | CYP11B2CYP11B1MIFCYP19A1ALDH1A1 | |
| SCHEMBL1959449 | 0.80 | GRM5 (0.60) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL28734542 | 0.75 | ALDH1A1 (0.48) | CYP11B2CYP11B1GRM5LMNAALDH1A1 | |
| SCHEMBL4252798 | 0.75 | EPHX2 (0.61) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL30712752 | 0.73 | CYP11B2 (1.00) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL6188982 | 0.73 | CYP11B2 (1.00) | CYP11B2CHRNB2CHRNA5CHRNA4CYP11B1 | |
| SCHEMBL9038455 | 0.73 | PTGS2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102089297-A | Novel 1,2,4 oxadiazole compounds and methods of use thereof | ABBOTT LAB | 2011-06-08 | — | — | CN | disclosed |