Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Triphenylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.37 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27319143 | 0.94 | CXCR2 (0.53) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL8821206 | 0.84 | CA1 (0.56) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL780030 | 0.84 | CA1 (0.56) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL28078111 | 0.84 | CA1 (0.44) | CXCR2CXCR1CA1CA2CA9 | |
| Acetic Acid SCHEMBL27484648 | 0.83 | CXCR2 (0.49) | CXCR2CXCR1CA1CA2CA9 | |
| Methanesulfonamide SCHEMBL27516919 | 0.83 | CA2 (0.57) | CXCR2CXCR1CA1CA2CA9 | |
| Iodide SCHEMBL3347577 | 0.82 | CA1 (0.54) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL6923665 | 0.82 | CA1 (0.54) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL1128833 | 0.82 | CA1 (0.54) | CXCR2CXCR1CA1CA2CA9 | |
| SCHEMBL28807949 | 0.82 | CA1 (0.54) | CXCR2CXCR1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103094490-B | Organic Selenium material and the purposes in organic light emitting apparatus thereof | UNIVERSAL DISPLAY CORP. (US) | 2016-03-09 | — | — | CN | disclosed |
| CN-102160206-B | Organic selenium substance and use thereof in organic light emitting device | UNIVERSAL DISPLAY CORP | 2014-06-11 | — | — | CN | disclosed |
| CN-103094490-A | Organoselenium materials and their uses in organic light emitting devices | UNIVERSAL DISPLAY CORP | 2013-05-08 | — | — | CN | disclosed |
| CN-102160206-A | Organic selenium substance and use thereof in organic light emitting device | UNIVERSAL DISPLAY CORP | 2011-08-17 | — | — | CN | disclosed |