Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.73 |
| ▸ | APP | P05067 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 3/20 | 0.69 |
| ▸ | MMP2 | P08253 | 2/20 | 0.66 |
| ▸ | MMP8 | P22894 | 2/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.58 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27821015 | 0.91 | MMP2 (0.82) | MAPK1HTTPOLBSMN1; SMN2APP | |
| SCHEMBL24993421 | 0.90 | MMP2 (0.80) | MAPK1HTTPOLBSMN1; SMN2KDR | |
| SCHEMBL15401066 | 0.89 | KDR (0.74) | MAPK1HTTPOLBSMN1; SMN2APP | |
| SCHEMBL30989359 | 0.83 | MMP2 (0.66) | MAPK1HTTPOLBSMN1; SMN2KDR | |
| SCHEMBL30173490 | 0.81 | MMP2 (0.78) | HTTSMN1; SMN2MMP2MMP8NPC1 | |
| SCHEMBL27235580 | 0.81 | MMP2 (0.78) | HTTSMN1; SMN2MMP2MMP8NPC1 | |
| SCHEMBL15401374 | 0.80 | MMP2 (1.00) | HTTSMN1; SMN2MMP2MMP8NPC1 | |
| SCHEMBL16458931 | 0.79 | MMP2 (0.86) | MAPK1HTTPOLBSMN1; SMN2KDR | |
| SCHEMBL15403403 | 0.79 | ACHE (0.74) | MAPK1HTTPOLBSMN1; SMN2APP | |
| Hydrochloric Acid SCHEMBL31496761 | 0.79 | MMP2 (0.98) | HTTSMN1; SMN2MMP2MMP8NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102166214-B | Medical application of aminothiazole MyD88 specific inhibitor | AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH | 2012-12-12 | — | — | CN | claimed |
| CN-102166214-A | Medical application of aminothiazole MyD88 specific inhibitor | AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH | 2011-08-31 | — | — | CN | claimed |
| CN-102166214-B | Medical application of aminothiazole MyD88 specific inhibitor | AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH | 2012-12-12 | — | — | CN | disclosed |
| CN-102166214-A | Medical application of aminothiazole MyD88 specific inhibitor | AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV SCI & TECH | 2011-08-31 | — | — | CN | disclosed |