Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | AKT1 | P31749 | 5/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 4/20 | 0.33 |
| ▸ | KMO | O15229 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.33 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27821736 | 0.84 | KMO (0.33) | MPLAKT1EPHX1ARKMO | |
| SCHEMBL2338758 | 0.79 | EPHX1 (0.36) | MPLAKT1EPHX1ARKMO | |
| Hydrochloric Acid SCHEMBL2349140 | 0.78 | EPHX1 (0.35) | MPLAKT1EPHX1ARKMO | |
| SCHEMBL27664128 | 0.76 | AKR1C3 (0.39) | ARKIF11SCN8AHDAC8 | |
| SCHEMBL2339031 | 0.76 | KIF11 (0.36) | MPLARKMOKIF11SCN8A | |
| SCHEMBL16464213 | 0.76 | PNMT (0.54) | RPS6KB1 | |
| SCHEMBL20551738 | 0.76 | KIF11 (0.36) | MPLARKMOKIF11SCN8A | |
| SCHEMBL7020637 | 0.76 | KMO (0.38) | AKT1ARKMOKIF11SCN8A | |
| SCHEMBL27840751 | 0.75 | AKR1C3 (0.44) | AKT1EPHX1SCN8ANR3C2 | |
| SCHEMBL5463963 | 0.72 | AR (0.34) | EPHX1ARKIF11SCN8AVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102209538-A | Combination therapy of P70S 6 kinase inhibitors and EGFR inhibitors | LILLY CO ELI | 2011-10-05 | — | — | CN | disclosed |
| CN-102209539-A | Combination therapy of P70S 6 kinase inhibitors and MTOR inhibitors | LILLY CO ELI | 2011-10-05 | — | — | CN | disclosed |