Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784159 | 0.79 | PIK3CD (0.40) | HDAC1HDAC8HDAC6PIK3CDEPHX2 | |
| SCHEMBL2785941 | 0.77 | PGR (0.47) | PIK3CDPGR | |
| SCHEMBL2786310 | 0.74 | PGR (0.46) | PIK3CDALOX5APFEN1PGR | |
| SCHEMBL2785052 | 0.73 | PIK3CD (0.40) | HDAC1HDAC8HDAC6PIK3CDEPHX2 | |
| SCHEMBL3041430 | 0.72 | ITGB2 (0.32) | PIK3CD | |
| SCHEMBL2786464 | 0.72 | PGR (0.39) | PIK3CDPIM1PGR | |
| SCHEMBL3020049 | 0.71 | PGR (0.55) | HDAC1HDAC8HDAC6PIK3CDEPHX2 | |
| SCHEMBL2786628 | 0.70 | GRIN1 (0.38) | HDAC1HDAC8HDAC6EPHX2PGR | |
| SCHEMBL2785852 | 0.70 | PGR (0.41) | PIK3CDEPHX2PGR | |
| SCHEMBL2785718 | 0.69 | PIM1 (0.39) | PIK3CDPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2209373-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | Merck Sharp & Dohme Corp. (US) | 2010-07-28 | — | — | EP | claimed |
| WO-2009045386-A1 | N-SUBSTITUTED OXINDOLINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |