Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27967176 | 0.84 | TLR8 (0.58) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL27933392 | 0.82 | NOTUM (0.66) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL29082677 | 0.81 | NOTUM (0.47) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL28826453 | 0.81 | NOTUM (0.48) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL27868448 | 0.80 | NOTUM (0.62) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL28826450 | 0.80 | NOTUM (0.47) | TSHRTLR8RAB9ANPC1NOTUM | |
| Ethoxycarbonyl Group SCHEMBL29082690 | 0.75 | NOTUM (0.48) | TLR8RAB9ANPC1NOTUMTP53 | |
| Ethoxycarbonyl Group SCHEMBL27921877 | 0.72 | PTGS2 (0.50) | TLR8RAB9ANPC1NOTUMTP53 | |
| SCHEMBL12896182 | 0.72 | NOTUM (0.62) | TSHRTLR8RAB9ANPC1NOTUM | |
| SCHEMBL27851505 | 0.72 | MAPT (0.45) | TSHRRAB9ANPC1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103209979-B | therapeutic agent 976 | ASTRAZENECA AB (SE) | 2016-02-10 | — | — | CN | disclosed |
| CN-102459279-B | Therapeutic agents 713 | ASTRAZENECA AB | 2014-06-25 | — | — | CN | disclosed |
| CN-102459279-A | Therapeutic agents 713 | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |