Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187400 | 0.80 | KCNJ1 (0.51) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL287709 | 0.77 | NPC1 (0.49) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL287239 | 0.76 | NPC1 (0.53) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL28869852 | 0.76 | NPC1 (0.48) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL17633961 | 0.75 | KMT2A (0.51) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL12824117 | 0.74 | NPC1 (0.57) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL27851991 | 0.73 | POLB (0.51) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL30276673 | 0.72 | POLB (0.46) | NPC1MAPTRAB9ANPSR1KDM4E | |
| SCHEMBL27906089 | 0.71 | LMNA (0.54) | RAB9AKDM4E | |
| SCHEMBL14544647 | 0.70 | MAPT (0.71) | NPC1MAPTRAB9ANPSR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102421760-A | Dihydropyrimidinones useful as BACE2 inhibitors | HOFFMANN LA ROCHE | 2012-04-18 | — | — | CN | disclosed |