Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | LIPE | Q05469 | 12/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL217941 | 0.86 | TSHR (0.50) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL9862017 | 0.84 | LMNA (0.51) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL10435427 | 0.83 | RAB9A (0.50) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL6634752 | 0.83 | KMT2A (0.57) | LMNALIPEKMT2ABCHERAB9A | |
| SCHEMBL31387018 | 0.79 | KMT2A (0.47) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL28028552 | 0.78 | L3MBTL1 (0.50) | LMNASMN1; SMN2LIPEKMT2ARAB9A | |
| SCHEMBL27653581 | 0.78 | LMNA (0.56) | LMNASMN1; SMN2LIPEKMT2ARAB9A | |
| SCHEMBL27902251 | 0.77 | LMNA (0.46) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL17440372 | 0.77 | TSHR (0.60) | LMNATSHRSMN1; SMN2LIPEKMT2A | |
| SCHEMBL27911352 | 0.77 | LMNA (0.42) | LMNALIPEKMT2ARAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105218523-B | Pyridine derivate PIM kinase inhibitor and preparation method thereof and the application in pharmacy | 上海吉铠医药科技有限公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-105254624-B | Isothizole derivatives PIM kinase inhibitor and preparation method thereof and the application in pharmacy | 上海吉铠医药科技有限公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-105130959-B | Pyrimidine derivatives PIM kinase inhibitors and preparation method thereof and the application in pharmacy | 上海吉铠医药科技有限公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-105254624-A | Isothiazole derivative PIM kinase inhibitor and preparation method thereof, and application of inhibitor in pharmacy | SHANGHAI JIKAI MEDICAL TECHNOLOGY CO LTD | 2016-01-20 | — | — | CN | disclosed |
| CN-105218523-A | Pyridine derivate PIM kinase inhibitor and preparation method thereof and the application in pharmacy | SHANGHAI JIKAI PHARMACEUTICAL TECHNOLOGY CO LTD | 2016-01-06 | — | — | CN | disclosed |
| CN-105130959-A | PIM (provims integration of maloney) kinase inhibitor adopting pyrimidine derivative structure, preparation method of PIM kinase inhibitor and application of PIM kinase inhibitor to pharmacy | SHANGHAI JIKAI MEDICAL TECHNOLOGY CO LTD | 2015-12-09 | — | — | CN | disclosed |
| CN-104837831-A | Novel pyridine derivatives | HOFFMANN LA ROCHE | 2015-08-12 | — | — | CN | disclosed |
| CN-104744403-A | Iminothiadiazine Dioxide Compounds As Bace Inhibitors, Compositions, And Their Use | MERCK SHARP & DOHME | 2015-07-01 | — | — | CN | disclosed |
| CN-103608332-A | Pyridine-2-amides useful as CB2 agonists | HOFFMANN LA ROCHE | 2014-02-26 | — | — | CN | disclosed |
| CN-102892758-A | Pyridine and pyrazine derivatives for the treatment of CF | NOVARTIS AG | 2013-01-23 | — | — | CN | disclosed |