Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 5/20 | 0.50 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 6/20 | 0.40 |
| ▸ | JAK1 | P23458 | 6/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2784233 | 0.88 | ORAI1 (0.58) | STIM1ORAI1LCLAT1KMT2APOLB | |
| SCHEMBL1828476 | 0.85 | STIM1 (0.63) | F11STIM1ORAI1LCLAT1JAK2 | |
| SCHEMBL2785071 | 0.78 | ORAI1 (0.73) | STIM1ORAI1MAPTPOLBMAPK1 | |
| SCHEMBL2785788 | 0.76 | KCNMA1 (0.51) | STIM1ORAI1KMT2APOLBMEN1 | |
| SCHEMBL2785487 | 0.74 | HTR2A (0.43) | LMNAKCNMA1RAB9A | |
| SCHEMBL2784884 | 0.73 | IL2 (0.42) | STIM1ORAI1JAK2JAK3GSK3A | |
| SCHEMBL1823693 | 0.72 | ORAI1 (0.81) | STIM1ORAI1LCLAT1MAPTKMT2A | |
| SCHEMBL1827870 | 0.68 | POLB (0.53) | F11ORAI1JAK2JAK1TYK2 | |
| SCHEMBL31417771 | 0.68 | FAAH (0.55) | MAPTKMT2ALMNAPOLBMEN1 | |
| SCHEMBL19106126 | 0.67 | F11 (1.00) | F11KLKB1MAPTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651232-B1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2010-12-22 | — | — | EP | claimed |