Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785082 | 0.86 | NPC1 (0.55) | ALDH1A1L3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL2788689 | 0.82 | POLB (0.52) | ALDH1A1HPGDMAPTKMT2AMEN1 | |
| SCHEMBL2787147 | 0.79 | BRAF (0.49) | ALDH1A1GAAMAPTKMT2AMEN1 | |
| SCHEMBL2786203 | 0.78 | MAPT (0.48) | ALDH1A1HPGDHSD17B10GAAMAPT | |
| SCHEMBL2785931 | 0.77 | GHSR (0.47) | ALDH1A1GAAL3MBTL1MAPTKMT2A | |
| SCHEMBL2773318 | 0.74 | KDM4E (0.49) | ALDH1A1HPGDHSD17B10GAAL3MBTL1 | |
| SCHEMBL2787557 | 0.74 | KCNA5 (0.47) | ALDH1A1HPGDHSD17B10GAAMAPT | |
| SCHEMBL2438795 | 0.70 | SMN1; SMN2 (0.56) | ALDH1A1GAAMAPTKMT2AHIF1A | |
| SCHEMBL2787412 | 0.70 | GAA (0.47) | HPGDGAAMAPTKMT2AMEN1 | |
| SCHEMBL6196491 | 0.68 | KCNA5 (0.47) | ALDH1A1HPGDHSD17B10GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |