Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785082 | 0.80 | NPC1 (0.55) | MAPTKDM4EALDH1A1TP53KMT2A | |
| SCHEMBL2787412 | 0.79 | GAA (0.47) | MAPTHPGDTP53KMT2AMEN1 | |
| SCHEMBL2785337 | 0.78 | ALDH1A1 (0.46) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2786010 | 0.74 | CYP1A2 (0.43) | MAPTALDH1A1HPGDTP53NPC1 | |
| SCHEMBL2770313 | 0.74 | RAB9A (0.58) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2768967 | 0.74 | KCNA5 (0.56) | MAPTKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2785931 | 0.73 | GHSR (0.47) | MAPTALDH1A1TP53KMT2AMEN1 | |
| SCHEMBL2788689 | 0.73 | POLB (0.52) | MAPTALDH1A1HPGDTP53KMT2A | |
| SCHEMBL2787147 | 0.72 | BRAF (0.49) | MAPTALDH1A1KMT2AMEN1RAB9A | |
| SCHEMBL2787148 | 0.71 | KMT2A (0.43) | KDM4EALDH1A1HPGDHSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |