Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | RAF1 | P04049 | 6/20 | 0.48 |
| ▸ | KDR | P35968 | 5/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | LYN | P07948 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | FER | P16591 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785337 | 0.79 | ALDH1A1 (0.46) | MAPTLMNAGAARAB9AKDR | |
| SCHEMBL2769617 | 0.78 | KDR (0.53) | BRAFMAPTLMNAGAARAB9A | |
| SCHEMBL2785082 | 0.78 | NPC1 (0.55) | MAPTLMNARAB9AMEN1KMT2A | |
| SCHEMBL2785931 | 0.77 | GHSR (0.47) | MAPTLMNAGAARAB9AKDR | |
| SCHEMBL2788689 | 0.74 | POLB (0.52) | MAPTRAB9AHTTMEN1KMT2A | |
| SCHEMBL2786524 | 0.73 | HIF1A (0.40) | MAPTLMNAGAARAB9ARAF1 | |
| SCHEMBL22339322 | 0.72 | MAPT (0.69) | BRAFMAPTLMNAGAARAB9A | |
| SCHEMBL2786203 | 0.72 | MAPT (0.48) | MAPTGAARAB9AAURKAROCK2 | |
| SCHEMBL19668140 | 0.71 | KDR (0.74) | BRAFMAPTLMNAGAARAB9A | |
| SCHEMBL2769621 | 0.71 | KCNA5 (0.41) | BRAFMAPTLMNAGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |