Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.34 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.34 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2786524 | 0.81 | HIF1A (0.40) | LMNAMAPTKITKDRFLT3 | |
| SCHEMBL2769040 | 0.81 | HTR4 (0.36) | LMNAALDH1A1MAPTCYP2C9HTR4 | |
| SCHEMBL2769042 | 0.78 | ALDH1A1 (0.36) | LMNAALDH1A1MAPTCYP2C9HTR4 | |
| SCHEMBL2787572 | 0.66 | MAPT (0.38) | LMNAMAPTMEN1KMT2AIDO1 | |
| Cyclohexane SCHEMBL2442882 | 0.64 | KCNA5 (0.39) | LMNAMAPTKITKDRMEN1 | |
| SCHEMBL2785339 | 0.61 | HIF1A (0.45) | LMNAALDH1A1MAPTKITKDR | |
| Cyclohexane SCHEMBL2440712 | 0.61 | SCN9A (0.37) | KITKDRFLT3HTR4KMT2A | |
| SCHEMBL10765895 | 0.61 | ALDH1A1 (0.58) | LMNAALDH1A1MAPTCYP2C9MEN1 | |
| SCHEMBL19647610 | 0.61 | ALDH1A1 (0.58) | LMNAALDH1A1MAPTCYP2C9MEN1 | |
| SCHEMBL2768798 | 0.60 | KCNA5 (0.45) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |