Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | FLT3 | P36888 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787618 | 0.84 | KDR (0.48) | HIF1ARAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2788286 | 0.81 | HIF1A (0.61) | HIF1ARAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2767956 | 0.77 | HIF1A (0.46) | HIF1ARAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2786010 | 0.77 | CYP1A2 (0.43) | AURKBRAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2785205 | 0.72 | ALDH1A1 (0.38) | HIF1AAURKBRAB9AMAPTNPC1 | |
| SCHEMBL2786524 | 0.72 | HIF1A (0.40) | HIF1AAURKBRAB9AMAPTNPC1 | |
| SCHEMBL2785931 | 0.71 | GHSR (0.47) | AURKBRAB9AMAPTNPC1KMT2A | |
| SCHEMBL2785840 | 0.71 | NOX1 (0.36) | HIF1AAURKBMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2785719 | 0.71 | AURKB (0.42) | AURKBRAB9AMAPTNPC1SMN1; SMN2 | |
| SCHEMBL2784439 | 0.70 | KIT (0.39) | HIF1AAURKBMAPTALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |