Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787441 | 0.89 | TP53 (0.47) | MAPTTP53SMN1; SMN2HIF1AALOX15 | |
| SCHEMBL2437430 | 0.80 | SMN1; SMN2 (0.57) | MAPTTP53SMN1; SMN2TSHRKMT2A | |
| SCHEMBL2786321 | 0.79 | TP53 (0.44) | TP53SMN1; SMN2ALOX15TSHRKCNJ6 | |
| SCHEMBL2787210 | 0.77 | KIT (0.41) | MAPTTP53SMN1; SMN2HIF1AALDH1A1 | |
| SCHEMBL2785764 | 0.76 | ABCC9 (0.45) | MAPTTP53SMN1; SMN2ALOX15TSHR | |
| SCHEMBL2787058 | 0.75 | TP53 (0.46) | MAPTTP53SMN1; SMN2HIF1AALOX15 | |
| SCHEMBL2768640 | 0.75 | MAPT (0.50) | MAPTSMN1; SMN2HIF1AKMT2AALDH1A1 | |
| SCHEMBL2787344 | 0.73 | TP53 (0.50) | MAPTTP53SMN1; SMN2HIF1AALOX15 | |
| SCHEMBL2784161 | 0.73 | STK17B (0.41) | MAPTTP53SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL2785867 | 0.71 | SMN1; SMN2 (0.47) | MAPTTP53SMN1; SMN2HIF1AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |