Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2787017 | 0.90 | MAPT (0.43) | KITKDRHIF1ASMN1; SMN2NPC1 | |
| SCHEMBL2783769 | 0.87 | USP2 (0.36) | HIF1ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2784439 | 0.84 | KIT (0.39) | KITKDRHIF1AMAPTTP53 | |
| SCHEMBL2785719 | 0.83 | AURKB (0.42) | KITKDRSMN1; SMN2NPC1RAB9A | |
| SCHEMBL2785840 | 0.83 | NOX1 (0.36) | KITKDRHIF1ASMN1; SMN2NPC1 | |
| SCHEMBL2784783 | 0.82 | MAPT (0.39) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL2786452 | 0.81 | MAPT (0.46) | KITKDRHIF1ASMN1; SMN2RAB9A | |
| SCHEMBL2438912 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AMAPTTP53 | |
| SCHEMBL2785205 | 0.78 | ALDH1A1 (0.38) | HIF1ASMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL2785392 | 0.77 | MAPT (0.42) | HIF1ASMN1; SMN2NPC1RAB9AEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |