SCHEMBL2785447

SCHEMBL2785447

O=C(O)C=Cc1ccc(O)c([N+](=O)[O-])c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH5A1 P51649 1/20 0.63
ABAT P80404 1/20 0.63
MAPT P10636 5/20 0.62
KDM4E B2RXH2 4/20 0.62
MAPK1 P28482 4/20 0.62
HSD17B10 Q99714 3/20 0.62
MEN1 O00255 3/20 0.62
KMT2A Q03164 3/20 0.62
CA12 O43570 3/20 0.62
CA1 P00915 3/20 0.62
CA2 P00918 3/20 0.62
CA3 P07451 3/20 0.62
CA4 P22748 3/20 0.62
CA6 P23280 3/20 0.62
CA5A P35218 3/20 0.62
CA7 P43166 3/20 0.62
CA9 Q16790 3/20 0.62
CA14 Q9ULX7 3/20 0.62
CA5B Q9Y2D0 3/20 0.62
ALDH1A1 P00352 3/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2785445 1.00 ALDH5A1 (0.63) ALDH5A1ABATMAPTKDM4EMAPK1
SCHEMBL7166946 1.00 ALDH5A1 (0.63) ALDH5A1ABATMAPTKDM4EMAPK1
SCHEMBL2264126 0.87 KDM4E (0.62) ALDH5A1ABATMAPTKDM4EMAPK1
SCHEMBL2264118 0.87 KDM4E (0.62) ALDH5A1ABATMAPTKDM4EMAPK1
SCHEMBL10780080 0.84 MAPT (0.64) MAPTKDM4EMAPK1HSD17B10MEN1
SCHEMBL10797509 0.84 MAPT (0.64) MAPTKDM4EMAPK1HSD17B10MEN1
SCHEMBL25206964 0.84 KMT2A (0.75) ALDH5A1ABATMAPTMAPK1MEN1
SCHEMBL1903142 0.83 PLA2G4A (0.59) MAPTKDM4EMAPK1HSD17B10MEN1
SCHEMBL15709537 0.83 PLA2G4A (0.59) MAPTKDM4EMAPK1HSD17B10MEN1
SCHEMBL2910060 0.83 LMNA (0.55) MAPTKDM4EMAPK1HSD17B10MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11421223-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2022-08-23 US disclosed
CN-113880695-A Preparation method of 4-vinylphenol compound 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2022-01-04 CN disclosed
CN-108840899-B Pentacyclic triterpenoid compound and derivative and application thereof 浙江大学 2020-11-10 CN disclosed
US-20190309289-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2019-10-10 US disclosed
US-10370654-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. (US) 2019-08-06 US disclosed
US-20180320170-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2018-11-08 US disclosed
US-9944925-B2 Processes and host cells for genome, pathway, and biomolecular engineering ENEVOLV, INC. 2018-04-17 US disclosed
US-20160186168-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. 2016-06-30 US disclosed
EP-3027754-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING enEvolv, Inc. (US) 2016-06-08 EP disclosed
WO-2015017866-A1 PROCESSES AND HOST CELLS FOR GENOME, PATHWAY, AND BIOMOLECULAR ENGINEERING ENEVOLV, INC. (US) 2015-02-05 WO disclosed
US-5972970-A COMPOUNDS SUCH AS 5-(3-(2-(2-(5-METHYL-2-PHENYL-4-OXAZOLYL) ETHOXYL-5-PYRIDYL)PROPYL)-2,4-OXAZOLIDINEDIONE; ADMINISTERING TO TREAT A MAMMAL SUFFERING FROM DIABETES OR HYPERLIPIDEMIA TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-26 US disclosed
CN-1036064-C Benzene derivatives having NGF production-promoting activity SANKYO CO (JP) 1997-10-08 CN disclosed
EP-0612743-B1 Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1997-09-10 EP disclosed
US-5665748-A ANTIDIABETIC, HYPOLIPIDEMIC AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-09 US disclosed
US-5643925-A COGNITION ACTIVATORS AND NERVE GROWTH FACTORS SANKYO COMPANY, LIMITED (JP) 1997-07-01 US disclosed
US-5614521-A NERVE GROWTH FACTOR SANKYO COMPANY, LIMITED (JP) 1997-03-25 US disclosed
EP-0501656-B1 New benzene derivatives having (NGF) production-promoting activity SANKYO CO (JP) 1997-01-22 EP disclosed
EP-0612743-A1 Oxazolidinedione derivatives, their production and use in lowering blood sugar and lipid levels TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-31 EP disclosed
CN-1064273-A The new NGF that has generates the active benzene derivative of promotion SANKYO CO (JP) 1992-09-09 CN disclosed
EP-0501656-A2 New benzene derivatives having (NGF) production-promoting activity Sankyo Company Limited (JP) 1992-09-02 EP disclosed