SCHEMBL278549

SCHEMBL278549

C=CCn1ccc(N)nc1=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.46
FGFR1 P11362 2/20 0.42
SLC22A6 Q4U2R8 1/20 0.41
PDE3A Q14432 3/20 0.36
PDE4D Q08499 1/20 0.36
SLC29A1 Q99808 1/20 0.36
EGFR P00533 1/20 0.36
LMNA P02545 3/20 0.35
THRB P10828 1/20 0.35
MTOR P42345 1/20 0.35
MDM2 Q00987 1/20 0.35
NCOA1 Q15788 1/20 0.35
NCOA3 Q9Y6Q9 1/20 0.35
CYP19A1 P11511 1/20 0.35
ALDH1A1 P00352 1/20 0.35
EP300 Q09472 4/20 0.34
CACNA1F O60840 2/20 0.34
ALB P02768 2/20 0.34
MAPT P10636 2/20 0.34
CACNA1D Q01668 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29138425 0.84 FGFR1 (0.43) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL4595441 0.81 FGFR1 (0.41) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL27566188 0.79 FGFR1 (0.44) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL16446911 0.79 FGFR1 (0.47) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL20919715 0.77 FGFR1 (0.46) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL23343373 0.76 FGFR1 (0.44) FGFR1SLC22A6PDE3ALMNATHRB
SCHEMBL19901038 0.76 FGFR1 (0.44) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL236000 0.76 FGFR1 (0.51) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL24709494 0.76 FGFR1 (0.44) FGFR1SLC22A6PDE3APDE4DSLC29A1
SCHEMBL6751072 0.76 FGFR1 (0.44) FGFR1SLC22A6PDE3APDE4DSLC29A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 112 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116987495-A Construction and application of protein membrane macromolecular probe for biological detection 江南大学 2023-11-03 CN claimed
WO-2023141474-A9 POLY-TAILED AND POLY-CAPPED MRNA AND USES THEREOF THE BROAD INSTITUTE, INC. (US) 2023-10-26 WO claimed
WO-2023114963-A1 COMPOSITIONS AND METHODS FOR SELECTIVELY LABELING SECONDARY AMINES EMORY UNIVERSITY (US) 2023-06-22 WO claimed
CN-114807328-A Method for marking and identifying single-base resolution DNA 浙江大学 2022-07-29 CN claimed
CN-112301118-B Method and kit for simultaneously obtaining RNA abundance and active RNA polymerase sites in full transcriptome range 浙江大学 2022-05-13 CN claimed
CN-112301118-A Method and kit for simultaneously obtaining RNA abundance and active RNA polymerase sites in full transcriptome range 浙江大学 2021-02-02 CN claimed
US-20020160969-A1 Nucleosides and oligonucleotides containing boron clusters DEPARTMENT OF VETERANS AFFAIRS 2002-10-31 US claimed
EP-1113020-A2 Nucleosides and oligonucleotides containing boron clusters EMORY UNIVERSITY (US) 2001-07-04 EP claimed
US-6180766-B1 OLIGONUCLEOTIDE WITH UNCHARGED INTERNUCLEOTIDE LINKAGE(S) OF 3',5'-O,O-((CARBORAN-1-YL-METHYL)PHOSPHONATE); MADE BY REACTING O-METHYL(O-CARBORAN-1-YL)METHYL PHOSPHONATE WITH PROTECTED NUCLEOSIDE; USE IN BORON NEUTRON CAPTURE THERAPY DEPARTMENT OF VETERANS AFFAIRS 2001-01-30 US claimed
EP-0731808-A4 NUCLEOSIDES AND OLIGONUCLEOTIDES CONTAINING BORON CLUSTERS UNIV EMORY (US) 1997-04-02 EP claimed
EP-0731808-A1 NUCLEOSIDES AND OLIGONUCLEOTIDES CONTAINING BORON CLUSTERS EMORY UNIVERSITY (US) 1996-09-18 EP claimed
WO-1995015333-A1 NUCLEOSIDES AND OLIGONUCLEOTIDES CONTAINING BORON CLUSTERS EMORY UNIVERSITY (US) 1995-06-08 WO claimed
US-20240158433-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, LLC (US) 2024-05-16 US disclosed
US-20240140982-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS TRILINK BIOTECHNOLOGIES, LLC (US) 2024-05-02 US disclosed
WO-2024044741-A2 EFFICIENT METHOD FOR MAKING HIGHLY PURIFIED 5'-CAPPED OLIGONUCLEOTIDES TRILINK BIOTECHNOLOGIES, LLC (US) 2024-02-29 WO disclosed
EP-4104687-B1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5 -CAPPED RNAS TRILINK BIOTECHNOLOGIES LLC (US) 2024-01-31 EP disclosed
CN-1330634-A Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds GPINIL HOLDINGS INC (US) 2002-01-09 CN disclosed
EP-1163251-A1 N-ACYLPHOSPHORAMIDITES AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2001-12-19 EP disclosed
US-20010044529-A1 Thermolabile phosphorus protecting groups, associated intermediates and methods of use GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES 2001-11-22 US disclosed
WO-2000056749-A1 N-ACYLPHOSPHORAMIDITES AND THEIR USE IN OLIGONUCLEOTIDE SYNTHESIS THE GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2000-09-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020160969-A1 Nucleosides and oligonucleotides containing boron clusters NUDT1, NTPCR, NAMPT SLC2A1 697/4885FGFR1 1690/4885SLC22A6 271/4885
US-20240140982-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B SLC2A1 4812/4885FGFR1 4688/4885SLC22A6 3638/4885
US-20010044529-A1 Thermolabile phosphorus protecting groups, associated intermediates and methods of use POLR2H, POLL, POLR1A SLC2A1 2019/4885FGFR1 1128/4885SLC22A6 2574/4885
US-20240158433-A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING 5'-CAPPED RNAS RNGTT, RNMT, NT5C3B SLC2A1 4812/4885FGFR1 4688/4885SLC22A6 3638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.