Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2874448 | 0.87 | KDM4E (0.37) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL10674301 | 0.86 | FAAH (0.38) | OPRK1FAAHMEN1ALDH1A1GAA | |
| SCHEMBL366956 | 0.78 | KDM1A (0.46) | OPRK1ALDH1A1 | |
| SCHEMBL2786999 | 0.78 | SIRT1 (0.52) | OPRK1SIRT1FAAHSMN1; SMN2 | |
| SCHEMBL10680765 | 0.78 | NPC1 (0.41) | MEN1ALDH1A1GAAMAPTHPGD | |
| SCHEMBL16175613 | 0.78 | OPRK1 (0.57) | OPRK1ALDH1A1MAPTKDM4E | |
| SCHEMBL12213073 | 0.77 | CYP4F2 (0.36) | FAAHMEN1ALDH1A1GAAMAPT | |
| SCHEMBL7275357 | 0.77 | ALDH1A1 (0.53) | FAAHMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL4794024 | 0.76 | DRD3 (0.42) | OPRK1SIRT1FAAHITGB3ITGA2B | |
| SCHEMBL346421 | 0.75 | PLAU (0.52) | FAAHALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2396300-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI (FR) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010092153-A1 | NEW SUBSTITUTED TETRAHYDRONAPTHALENES, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF AS DRUGS | SANOFI-AVENTIS (FR) | 2010-08-19 | — | — | WO | disclosed |