Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.40 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27858578 | 0.84 | MBOAT4 (0.38) | TRAP1MEN1KMT2AMAPTTHRB | |
| SCHEMBL27841108 | 0.82 | ALDH1A1 (0.49) | P2RX7MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27841073 | 0.82 | MEN1 (0.45) | P2RX7MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL27841122 | 0.82 | KDM4E (0.44) | TRAP1L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27841077 | 0.80 | PTGDR2 (0.43) | ATMS1PR5 | |
| SCHEMBL27841067 | 0.77 | MEN1 (0.46) | MEN1KMT2AALDH1A1TSHRPOLB | |
| SCHEMBL27858820 | 0.77 | KDM4E (0.49) | MEN1KMT2AALDH1A1ATMKDM4E | |
| SCHEMBL27841074 | 0.76 | ESR2 (0.43) | P2RX7MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL27858676 | 0.74 | COMT (0.46) | P2RX7MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL8140213 | 0.70 | P2RX7 (0.48) | DAOP2RX7TRAP1MRGPRX4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102264740-B | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | FIBROGEN, INC. (US) | 2014-10-15 | — | — | CN | disclosed |
| CN-102264740-A | Pyrrolo [ 1, 2 -b] pyridazine derivatives and their use as hif modulators | — | 2011-11-30 | — | — | CN | disclosed |